HIV Management in 2026: The South African Context

South Africa carries the largest HIV burden globally. This review covers the latest ART guidelines, management of comorbidities, and the role of long-acting injectable antiretrovirals in the local setting.

By Prof. Sipho Dlamini 22 May 2026 9 min read 1 CPD

HIV Management in 2026: The South African Context — Caption: Infectious Diseases

Current Guidelines

The 2026 Southern African HIV Clinicians Society guidelines recommend dolutegravir-based first-line ART for all patients. Tenofovir alafenamide (TAF) is preferred over TDF in patients with renal impairment or osteoporosis.

Long-Acting ART

Cabotegravir + rilpivirine long-acting injectable regimen is now available in South Africa for selected patients with viral suppression.

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